崔家华助理研究员
办公电话：021-34204775
电子邮件：cpucjh@sjtu.edu.cn
通讯地址：上海市东川路800号上海交通老员工物药学楼7-502
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教育背景
2010 - 2014 澳门官方赌博软件，药物化学，博士
2007 - 2010 中国药科大学，药物分析学，硕士
2000 - 2004 中国药科大学，药学，学士
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工作经历
2021至今 中国赌博十大网站，助理研究员
2019 - 2020 澳门官方赌博软件环境科学与工程学院，助理研究员
2016 - 2018 香港理工大学应用生物及化学科技系，博士后
2014 - 2019 上海交通老员工命科学技术学院，博士后
2004 - 2007 中国药科大学中药学院，助理实验师
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研究方向
1）天然萘醌类化合物的全合成及结构改造
2）肿瘤耐药的机理研究及小分子药物逆转耐药
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科研项目
主持国家自然科学基金青年项目、博士后科学基金面上项目、博士后科学基金“香江学者计划”项目、澳门官方赌博软件医工交叉研究基金等科研项目。
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代表性论文专著
1. Jiahua Cui* and Jinping Jia*. Discovery of juglone and its derivatives as potent SARS-CoV-2 main proteinase inhibitors. Eur. J. Med. Chem., 2021, 225, 113789.
2. Jinyun Dong, Guang Huang, Qing Cui, Qingqing Meng, Shaoshun Li* and Jiahua Cui*. Discovery of Heterocycle-Containing α-Naphthoflavone Derivatives as Water-Soluble, Highly Potent and Selective Cyp1b1 Inhibitors. Eur. J. Med. Chem., 2021, 209, 112895.
3. Jiahua Cui*, Jiajun Qian, Larry Ming-cheung Chow and Jinping Jia*. Natural products targeting cancer stem cells: A revisit. Curr. Med. Chem., 2021, 28(33), 6773-6804.
4. Yubei Li#, Jiahua Cui# and Jinping Jia*. The Activation of Procarcinogens by CYP1A1/1B1 and Related Chemo-Preventive Agents: A Review. Curr. Cancer Drug Targets. 2021, 21(1), 21-54.
5. Junqi Cui#, Xiaobo Zhou#, Jia Huang, Jiahua Cui* and Jun Chen*. The Selective Antitumor Effect of Shikonin Derived DMAKO-20 on Melanoma through CYP1B1. Curr. Cancer Drug Targets, 2021, 21(3), 223-231.
6. Jiahua Cui* and Jinping Jia*. Natural COX-2 inhibitors as promising anti-inflammatory agents: an update. Curr. Med. Chem., 2021, 28(18), 3622-3646.
7. Jiahua Cui*, Shaoshun Li and Jinping Jia*. A regioselective synthesis of 7-methyl juglone and its derivatives. Nat. Prod. Res., 2020, DOI: 10.1080/14786419.2020.1761356.
8. Gege Sun, Iris L. Wong, Jiahua Cui, Zhen Liu, Bill T. Chan, Larry M. Chow. Investigate the mechanism of actions of flavonoid dimers in reversing doxorubicin resistance in breast cancer stem cells. Cancer Res., 2020, 80 (16 Suppl), Abstract nr 3795.
9. Jiajun Qian#, Jiahua Cui#, Shaoshun Li, Jun Chen*, Jinping Jia*. Anticancer natural products with collateral sensitivity: a review. Mini-Rev. Med. Chem., 2021, DOI:10.2174/1389557521666210112141455.
10. Jiahua Cui, Xu Zhang, Guang Huang, Qijiang Zhang, Jinyun Dong, Gege Sun, Qingqing Meng and Shaoshun Li. DMAKO-20 as a new multi-target anticancer prodrug activated by the tumor specific CYP1B1 enzyme. Mol. Pharmaceutics., 2019, 16 (1), 409-421.
11. Jiahua Cui*, Xiaoyang Liu and Larry M. C. Chow. Flavonoids as P-gp inhibitors: a systematic review of SARs. Curr. Med. Chem., 2019, 26 (25), 4799-4831.
12. Jiahua Cui, Qingqing Meng, Xu Zhang, Qing Cui, Wen Zhou and Shaoshun Li. Design and synthesis of new α-naphthoflavones as cytochrome P450 (CYP) 1B1 inhibitors to overcome docetaxel-resistance associated with CYP1B1 overexpression. J. Med. Chem., 2015, 58(8), 3534-3547.
13. Jiahua Cui and Shaoshun Li. Inhibitors and prodrugs targeting CYP1: a novel approach in cancer prevention and therapy. Curr. Med. Chem., 2014, 21(5), 519-552.
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荣誉奖励
2016 中国博士后管委会办公室-香港学者协会 “香江学者”奖